I was an undergraduate at Cambridge where my passion for molecular virology first began. I completed my PhD under the supervision of Andrew Lever in the Department of Medicine, understanding the control of HIV gene expression. I then moved to the National Institute of Medical Research (now Francis Crick Institute) in London where I helped to disprove the reported novel retrovirus XMRV’s link to human infection and disease. I then began my work on cellular inhibition of retroviruses, focusing on HIV. I moved back to Cambridge in 2015 as a Henslow Research Fellow at Downing College and an Associate Principal Investigator in the Department of Medicine where I continued my work on cellular inhibitors of HIV. In my current fellowship I will continue to unpick how the intricate interactions between cells and viruses during infection can dictate host response and help us understand normal cell behaviour using retroviruses, herpesviruses and coronaviruses as model systems.

Publications, Links, and Resources

  • Ordonez P, Kunzelmann S, Groom HCT, Yap M, Weising S, Meier C, Bishop KN, Taylor IA SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells 2017 Sci Rep 7:42824
  • Groom HC1,Arnold LH1, Kunzelmann S, Schwefel D, Caswell SJ, Ordonez P, Mann MC, Rueschenbaum S, Goldstone DC, Pennell S, Howell SA, Stoye JP, Webb M, Taylor IA, Bishop KN Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction 2015 PLoS Pathog11(10):e1005194

         (1 joint first authorship)

  • *Schwefel D, Groom HCT, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN & Taylor IA Structural basis of lentiviral subversion of a cellular protein degradation pathway 2014 Nature 505(7482):234-8 
  • Groom HCT, Warren AY, Neal DE, Bishop KN No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses 2012 PLoS One 7(3):e34221
  • Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, Walker PA, Kelly G, Haire LF, Yap MW, de Carvalho LP, Stoye JP, Crow YJ, Taylor IA, Webb M HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. 2011 Nature 480(7377):379-82
  • Groom HCT, Yap MW, Galão RP, Neil SJ, Bishop KN Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors2010 Proc Natl Acad Sci U S A107(11):5166-71
  • Groom HCT, Boucherit VC, Makinson K, Randal E, Baptista S, Hagan S, Gow JW, Mattes FM, Breuer J, Kerr JR, Stoye JP, Bishop KN Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome2010 Retrovirology 7:10
  • Groom HCT, Anderson EC, Dangerfield J, Lever AM Rev regulates translation of Human Immunodeficiency Virus Type-1 RNAs.2009 J Gen Virol 90(Pt 5):1141-7
  • Gooding C, Clark F, Wollerton MC, Grellscheid SN, Groom H, Smith CWA class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones 2006 Genome Biology 7(1):R1

Review and public interest articles:

  • Groom HCT, Bishop KN The tale of xenotropic murine leukemia virus-related virus 2012 J Gen Virol 93(Pt 5):915-24
  • Groom HCT, Anderson EC, Lever AM Rev: beyond nuclear export2009 J Gen Virol 90(Pt 6):1303-18
  • Groom HCT, The breastfeeding biochemist parent: planning pumping and perfectionism https://doi.org/10.1042/BIO20200018