I am a programme leader at the MRC Laboratory of Molecular Biology.
During my PhD I studied the mechanims of DNA interstrand crosslink repair. I went on to explore the mechanims through which aldehydes damage DNA. I now focus on understanding how genetic information is faithfully passed from one generation to the next.
Publications, Links, and Resources
Hill RJ, Crossan GP. DNA Cross-link repair safeguards genomic stability during premeiotic germ cell development Nature Genetics 2019 DOI:10.1038/s41588-019-0471-2
Garaycoechea JI, Crossan GP, Langevin F, Mulderrig L, Gibaud G, Gomes S, Yang F, Roerink S, Nik-Zainal S, Stratton M and Patel KJ. Alcohol-derived and endogenous aldehydes rearrange chromosomes and mutate stem cell genomes. Nature 2018; 553: 171-177
Crossan, GP. Metformin: Treating the Cause of Fanconi Anemia? Blood 2016; 128: 2748-50.
Crossan, GP, J. I. Garaycoechea, and K. J. Patel†. Do Mutational Dynamics in Stem Cells Explain the Origin of Common Cancers?. Cell Stem Cell 2015;16:111-2.
Pontel, L. B., I. V. Rosado, G. Burgos-Barragan, J. I. Garaycoechea, R. Yu, M. J. Arends, G. Chandrasekaran, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ. Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen. Molecular Cell 2015;60:177-88.
Hodskinson M, Silhan J, Crossan GP, Garaycoechea JI, Mukherjee S, Johnson C, Schärer O, Patel KJ. Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair. Molecular Cell 2014; 54: 472-484.
Oberbeck N, Langevin F, King G, de Wind N, Crossan GP†, Patel KJ†. Maternal aldehyde elimination during pregnancy preserves the fetal genome. Molecular Cell
2014; 55: 807-17
† corresponding author
Bakker, J. L., Van Mil, S. E., Crossan, GP, Sabbaghain, N., De Leeneder, K., Poope, B., Adank, M., Gille, H., Verheul, H., Meijers-Heijbohr, H., De Winter, J. P., Claes, K., Tischkowitz, M. & Waisfaisz, Q. Analysis of the novel Fanconi anemia gene SLX4/FANCP in familial breast cancer cases. Hum Mutat 2013;
34, 70-3.
Crossan GP, Patel KJ. The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA. J Pathology 2012; 226: 326-337.
Garaycoechea JI*, Crossan GP*, Langevin F, Daly M., Arends MJ, Patel K J. Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature 2012; 489, 571-5.
*these authors contributed equally to this work
Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PH, McIntyre RE, Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ, Patel KJ. Disruption of mouse Slx4, a regulator of structure- specific nucleases, phenocopies Fanconi anemia. Nature Genetics 2011; 43: 147-152.
Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ. Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 2011; 475: 53-58.
Rosado IV, Langevin F, Crossan GP, Takata M, Patel KJ. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Nature Structural and Molecular Biology 2011; 18: 1432-1434.